Published: 14 July 2017 Volume: 5 Issue: 4 Pages: 138-144
DOI: 10.11648/j.ajcem.20170504.16 ISSN: 2330-8125 (Print); 2330-8133 (Online)
Authors: Alice Branton, Snehasis Jana
Citation: Alice Branton, Snehasis Jana, The Use of Novel and Unique Biofield Energy Healing Treatment for the Improvement of Poorly Bioavailable Compound, Berberine in Male Sprague Dawley Rats, American Journal of Clinical and Experimental Medicine. Vol. 5, No. 4, 2017, pp. 138-144. doi: 10.11648/j.ajcem.20170504.16
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Berberine, an isoquinoline alkaloid based herbal medicine, is widely used as nutraceutical supplement for the prevention and treatment of various diseases viz. hypolipidemic, hypoglycemic, antiarrhythmic, antineoplastic, etc. The intestinal absorption and oral bioavailability of berberine is very low and almost negligible in humans. In this study, the relative oral bioavailability of berberine was studied, and the effects of The Trivedi Effect®-Energy of Consciousness Healing Treatment on animals and berberine were investigated through the measurement of plasma concentrations after oral administration in rats. The test item, berberine chloride was divided into two parts. One part was denoted as the control without any Biofield Energy Healing Treatment, while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Alice Branton. Additionally, one group of animals also received Consciousness Energy Healing Treatment per se by Alice under similar conditions. Berberine oral formulations were made and administrated by oral gavage at a dose of 150 mg per kg in groups viz. G1 (untreated berberine), G2 (Biofield Treated berberine) and G3 (Biofield Treated animals were received untreated berberine) group. The results showed that berberine had a very low oral plasma exposure of 179.92 ng/mL in the control group. The Biofield Energy Healing Treatment significantly enhanced the relative oral exposure (AUC0–t) of berberine by 233.40% and 35.62% in G2 and G3 groups, respectively compared to the control group. The Biofield Energy Treatment also improved plasma peak concentration (Cmax) of berberine by 37.7 and 1.4 times, in G2 and G3 groups, respectively compared to the control group. The absorption rate constant (Ka) of berberine in Biofield Energy Treatment group significantly increased by 100% (p < 0.05) in G2 group as compared to the control group (G1). The apparent oral plasma clearance of berberine decreased significantly (p < 0.01) by 81%, and 50% in G2 group and G3 group, respectively as compared to the control group. The enhanced bioavailability of berberine might be due to the alteration its physicochemical properties and thermal properties by Biofield Energy Treatment. Biofield Energy Healing Treatment is considered as an innovative strategy which opens new avenues to overcome poorly absorbed drug/nutraceuticals/herbal extracts and can also improve the therapeutic performance of orally active molecules. Thereby, the Biofield Energy Treated berberine chloride having improved bioavailability can significantly increase in antibacterial, anticancer, antidiabetic, anti-obesity, anti-ischemia, memory and cognition, inhibition of metabolic syndrome and neurodegenerative diseases.
The limitation of poor permeability of berberine was successfully overcome using Biofield Energy Healing Treatment (The Trivedi Effect® ) by Alice Branton to the test item and rats. The use of this unique Energy Therapy resulted in significant (p < 0.05) increase (233%) in the oral bioavailability and plasma peak concentration (Cmax) by 37.7 folds of berberine in the Biofield Energy Treated groups, compared to the control group. The absorption rate constant (Ka) of berberine in the Biofield Energy Treatment group showed significant increase by 100% (p < 0.05) in G2 group as compared to the control group. The apparent oral plasma clearance (CL/F) of berberine was significantly (p < 0.01) decreased by 81% and 50% in G2 and G3 groups, respectively as compared to the control group. It may be due to the significant increase in the aqueous solubility and intestinal permeability that improved oral bioavailability. Therefore, the oral exposure of poorly bioavailable compounds like berberine chloride can be improved using this unique Biofield Energy Healing Treatment. Thereby, the Biofield Energy Treated berberine chloride having improved bioavailability can significantly increase in the antibacterial, anticancer, antidiabetic, anti-obesity, anti-ischemia, memory and cognition, inhibition of metabolic syndrome and neurodegenerative diseases such as Alzheimer’s Anxiety and depression. The present findings clearly demonstrate that Biofield Energy Treated test item/formulation prepared through innovative process opens new avenues to overcome the demerits of poorly absorbed drug/nutraceuticals/herbal extracts by improving the therapeutic performance of orally active molecules. All these above results indicated that Biofield Energy Treatment to human per se and the product can be used as a Complementary and Alternative Medicine (CAM) and it has the potential to be an effective and safe for the treatment of different type of health illness.