Journal: Analytical & Bioanalytical Techniques PDF
Published: 14-Aug-15 Volume: 6 Issue: 5
DOI: 10.4172/2155-9872.1000265 ISSN: 2155-9872
Authors: Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Khemraj Bairwa and Snehasis Jana *
Citation: Trivedi MK, Branton A, Trivedi D, Nayak G, Bairwa K, et al. (2015) Spectroscopic Characterization of Disulfiram and Nicotinic Acid after Biofield Treatment. J Anal Bioanal Tech 6: 265 doi:10.4172/2155-9872.1000265
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Disulfiram is being used clinically as an aid in chronic alcoholism, while nicotinic acid is one of a B-complex vitamin that has cholesterol lowering activity. The aim of present study was to investigate the impact of biofield treatment on spectral properties of disulfiram and nicotinic acid. The study was performed in two groups i.e., control and treatment of each drug. The treatment groups were received Mr. Trivedis biofield treatment. Subsequently, spectral properties of control and treated groups of both drugs were studied using Fourier transform infrared (FT-IR) and Ultraviolet-Visible (UV-Vis) spectroscopic techniques. FT-IR spectrum of biofield treated disulfiram showed the shifting in wavenumber of C-H stretching from 1496 to 1506 cm-1 and C-N stretching from 1062 to 1056 cm-1. The intensity of S-S dihedral bending peaks (665 and 553 cm-1) was also increased in biofield treated disulfiram sample, as compared to control. FT-IR spectra of biofield treated nicotinic acid showed the shifting in wavenumber of C-H stretching from 3071 to 3081 cm-1 and 2808 to 2818 cm-1. Likewise, C=C stretching peak was shifted to higher frequency region from 1696 cm-1 to 1703 cm-1 and C-O (COO-) stretching peak was shifted to lower frequency region from 1186 to 1180 cm-1 in treated nicotinic acid.
UV spectrum of control and biofield treated disulfiram showed similar pattern of UV spectra. Whereas, the UV spectrum of biofield treated nicotinic acid exhibited the shifting of absorption maxima (?max) with respect of control i.e., from 268.4 to 262.0 nm, 262.5 to 256.4, 257.5 to 245.6, and 212.0 to 222.4 nm.
Over all, the FT-IR and UV spectroscopy results suggest an impact of biofield treatment on the force constant, bond strength, and dipole moments of treated drugs such as disulfiram and nicotinic acid that could led to change in their chemical stability as compared to control.
The FT-IR data of biofield treated disulfiram showed an alteration in the wavenumber of C-H and C-N stretching; whereas, wavenumbers of C-H, C=O, and C-O stretching, and =C-H bending were altered in biofield treated nicotinic acid, with respect of control. Also, the peak intensity at 553-665 cm-1 (S-S dihedral bending) was increased in biofield treated disulfiram, as compared to control. This alteration in wavenumber referred to alteration in the force constant and bond strength of respective group. The UV spectral data of biofield treated nicotinic acid also support the possible change in the structural property with respect of control.
In conclusion, the results suggest a significant impact of biofield treatment on structural property like force constant, bond strength, dipole moment, and energy gap between bonding and nonbonding orbital of treated drug with respect to control.