Physicochemical and Thermal Characterization of Biofield Energy Treated Polylactic-co-glycolic acid (PLGA)

Journal: Journal of Analytical, Bioanalytical and Separation Techniques PDF  

Published: January 14, 2019 Volume: 4 Issue: 1 Pages: 01-Jun

DOI: 10.15436/2476-1869.19.2026 ISSN: 2476-1869

Authors: Alice Branton, Mahendra Kumar Trivedi, Dahryn Trivedi, Gopal Nayak, Snehasis Jana

Citation: Alice, B., et al. Physicochemical and Thermal Characterization of Biofield Energy Treated Polylactic-co-glycolic acid (PLGA). (2019) J Anal Bioanal Sep Tech 4(1): 1- 6.

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Abstract

Polylactic-co-glycolic acid (PLGA) is a biodegradable copolymer. It has many applications in the pharmaceuticals and biomedical industries, but its degradation and stability is a major concern. The objective of this study was to evaluate the influence of the Trivedi Effect® on the physicochemical and thermal properties of PLGA using modern analytical techniques. The PLGA sample was divided into control and Biofield Energy Treated parts. The control sample did not obtain the Biofield Energy Treatment, whereas the treated PLGA was received the Trivedi Effect®-Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton. The particle size values of the treated PLGA were increased by 8.97%(d10), 8.79%(d50), 4.72%(d90), and 6.61%{D(4,3)}; thus, the surface area of treated PLGA was significantly decreased by 6.84% compared with the control sample. The latent heat of evaporation and fusion of the treated PLGA were significantly increased by 29.60% and 230.93%, respectively compared with the control sample. The residue amount was significantly increased by 21.99% in the treated PLGA compared to the control sample. The maximum thermal degradation temperature of the treated PLGA was increased by 2.30% compared with the control sample. It was concluded that the Trivedi Effect®-Consciousness Energy Healing Treatment might have generated a new form of PLGA which may show better powder flowability, thermal stability, and minimise the hydrolysis of the ester linkages of PLGA.This improved quality of PLGA would be a better choice for the pharmaceutical formulations (i.e., the drug like simvastatin, amoxicillin, and minocycline loaded PLGA nanoparticles) and manufacturing of biomedical devices, i.e., grafts, sutures, implants, surgical sealant films, prosthetic devices, etc., in the industry using it as a raw material

Conclusion

The Trivedi Effect®-Consciousness Energy Healing Treatment have a significant impact on the particle size, surface area, and thermal behaviors of PLGA. The particle size values of the Biofield Energy Treated PLGA powder sample at d10, d50, d90, and D(4,3) were increased by 8.97%, 8.79%, 4.72%, and 6.61%, respectively compared to the control sample. Therefore, the surface area of the Biofield Energy Treated PLGA was significantly decreased by 6.84% compared with the control sample. The ?Hevaporation and ?Hfusion of the Biofield Energy Treated PLGA were significantly increased by 29.60% and 230.93%, respectively compared with the control sample. The residue amount was 21.99% more in the Biofield Energy Treated PLGA compared to the control sample. The Tmax of the Biofield Energy Treated PLGA was increased by 2.3% compared with the control sample. The Trivedi Effect®-Consciousness Energy Healing Treatment might have introduced a new polymorphic form of PLGA which may show better powder flowability and minimise the hydrolysis of the ester linkages of PLGA. This improved quality of PLGA would be a better choice for the pharmaceutical formulations (i.e., the drug like simvastatin, amoxicillin, vancomycin, and minocycline loaded PLGA nanoparticles) and manufacturing of biomedical devices, i.e., grafts, sutures, implants, surgical sealant films, prosthetic devices, micro and nanoparticles in the industry using it as a raw material.