Journal: Natural Products Chemistry & Research PDF
Published: 21-Aug-15 Volume: 3 Issue: 5
DOI: 10.4172/2329-6836.1000186 ISSN: 2329-6836
Authors: Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Harish Shettigar, Khemraj Bairwa and Snehasis Jana*
Citation: Trivedi MK, Branton A, Trivedi D, Shettigar H, Bairwa K, et al. (2015) Fourier Transform Infrared and Ultraviolet-Visible Spectroscopic Characterization of Biofield Treated Salicylic Acid and Sparfloxacin. Nat Prod Chem Res 3: 186. doi:10.4172/2329-6836.1000186
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Salicylic acid is a naturally occurring derivative of benzoic acid, and widely used in organic synthesis and as a plant hormone. Sparfloxacin is fluorinated quinolone antibiotic having broad spectrum antimicrobial property. The present study was aimed to evaluate the impact of biofield treatment on spectral properties of salicylic acid and sparfloxacin using FT-IR and UV-Vis spectroscopic techniques. The study was carried out in two groups, one was set to control, and another was subjected to biofield treatment. FT-IR spectrum of treated salicylic acid showed the upstream shifting in wavenumber of C-H stretching from 2999 to 3004 cm-1 and 2831 to 2837 cm-1 and C=O asymmetric stretching vibration from 1670 to 1683 cm-1 and 1652 to 1662 cm-1. The peak intensity in treated salicylic acid at 1558 cm-1 (aromatic C=C stretching) and 1501 cm-1 (C-C stretching) was increased as compared to control. FT-IR spectrum of treated sparfloxacin showed a downstream shifting in wavenumber of C-H stretching from 2961 to 2955 cm-1 and 2848 to 2818 cm-1, and upstream shifting in wavenumber of C=O (pyridone) stretching from 1641 to 1648 cm-1. Besides, increased intensity of peaks in treated sparfloxacin was found at 1628 cm-1 [C=C stretching (pyridone)] and 1507 cm-1 (N-H bending) as compared to control. UV spectrum of biofield treated salicylic acid exhibited a shifting of wavelength (?max) from 295.8 to 302.4 nm and 231.2 to 234.4 nm, with respect to control. Likewise, biofield treated sparfloxacin showed the shifting in UV wavelength (?max) from 373.8 to 380.6 nm and 224.2 to 209.2 nm.
Over all, the results suggest that alteration in wavenumber of IR peaks in treated samples might be occurred due to biofield induced alteration in force constant and dipole moment of some bonds. The changes in UV wavelength (?max) of treated sample also support the FT-IR results. Due to alteration in force constant and bond strength, the chemical stability of structure of treated drugs might also be increased, which could be beneficial for self-life of biofield treated drugs.
The FT-IR data of both drugs showed an alteration in the wavenumber of some functional groups like C-H and C=O (COO-) in treated salicylic acid, and C-H, C=O (pyridine), and C-F in treated sparfloxacin as compared to their respective control. The increased intensity of peaks at 1558 and 1501 cm-1 was found in treated salicylic acid. While the increased intensity of peaks at 1628 and 1507 cm-1 was found in treated sparfloxacin, as compared to respective control. The UV spectra of both drugs showed a biofield induce shifting of wavelength (?max) as compared to control. This might be occurred due to some possible alteration in structural properties like force constant, bond strength, dipole moments etc. of treated drugs through the biofield treatment. Due to possible alterations in structural properties of treated drugs, the chemical stability might also be altered, which could be beneficial for the shelf life of pharmaceutical drugs.