Characterization of the Physicochemical and Thermal properties of the Biofield Energy Treated Flutamide Using PSA, PXRD, TGA/DTG, and DSC Analytical Techniques

Journal: Journal of Complementary Medicine and Alternative Healthcare PDF  Web

Published: January 29, 2019 Volume: 8 Issue: 5 Pages: 001-006

DOI: 10.19080/JCMAH.2019.08.555748 ISSN: 2572-1232 ISSN: 2572-1232

Authors: Alice Branton, Mahendra Kumar Trivedi, Dahryn Trivedi, Gopal Nayak and Snehasis Jana

Citation: Alice B, Mahendra K T, Dahryn T, Gopal N, Snehasis J. Characterization of the Physicochemical and Thermal properties of the Biofield Energy Treated Flutamide Using PSA, PXRD, TGA/DTG, and DSC Analytical Techniques. J Complement Med Alt Healthcare. 2019; 8(5): 555748. DOI:10.19080/JCMAH.2019.08.555748

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Abstract

Flutamide is an antiandrogen drug that blocks the action of testosterone by binding to the androgen receptor. This study was designed to determine the impact of the Trivedi Effect®-Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of flutamide. The test sample was divided into two parts, i.e., control and treated sample. The control part was known as untreated sample, while the treated part remotely received the Biofield Energy Healing Treatment by a renowned Biofield Energy Healer, Alice Branton. The study showed that the particle size values were significantly increased by 15.82%(d10), 16.36%(d50), 1.05%(d90), and 5.10% {D (4, 3)}; thus, the specific surface area was significantly decreased by 14.56% in the treated sample compared with the control sample. The PXRD peak intensities and crystallite sizes were significantly altered ranging from 7.02% to 29.41% and -9.17% to 17.86%, along with 2.84% increase in the average crystallite size in the treated flutamide compared to the control sample. The residue weight was significantly decreased by 64.16%; however, the maximum thermal degradation temperature was increased by 10.16% in the treated sample compared to the control sample. The latent heat of the treated sample reduced by 9.37% compared with the control sample. The results revealed the significant alteration in the crystallinity, particle size and thermal stability of the treated sample as compared to the untreated sample. Thus, the Biofield Energy Treated flutamide might improve the flowability, and compatibility compared with the untreated sample, that may help in designing a better pharmaceutical formulation in terms of its performance against various diseases.

Conclusion

The study revealed that the Trivedi Effect®-Consciousness Energy Healing Treatment showed a significant impact on the particle size distribution, crystallite sizes, peak intensities, and the thermal properties of flutamide. The particle size values of the Alice’s Biofield Energy Treated flutamide were increased significantly by 15.82%, 16.36%, 1.05%, and 5.10% at d10, d50, d90, and D (4, 3), respectively compared to the control sample. The specific surface area of the Biofield Energy Treated sample was found to be decreased by 14.56% compared to the untreated flutamide sample. The increase in particle size might be helpful in providing the better compactibility, uniformity, and flowability to the treated flutamide sample. The PXRD results showed alterations in the Bragg’s angle of the highest intensity peak as well as the other peaks of the treated sample. Also, the peak intensities and crystallite sizes corresponding to those peaks of the treated flutamide sample showed alterations ranging of 7.02% to 29.41% and -9.17% to 17.86%, respectively as compared to the untreated sample. Similarly, the average crystallite size of the Biofield Energy Treated flutamide sample was also increased by 2.84% compared to the control sample. Besides, the total weight loss of the Biofield Energy Treated sample was increased by 2.21% in TGA; whereas, the residue amount was significantly reduced by 64.16% as compared with the control sample. The DTG study showed that the Tmax of the Biofield Energy Treated flutamide sample was significantly improved by 10.16% compared with the control sample. The Biofield Energy Treated sample revealed that the melting temperature and ?Hfusion were decreased by 0.57% and 9.37%, respectively as compared to the untreated flutamide sample. Thus, the thermal analysis indicated the less thermal stability of the Biofield Energy Treated sample as compared to the control sample. Overall, the Trivedi Effect®-Consciousness Energy Healing Treatment poses its impact on the flutamide sample, which might generate its new polymorphic form with altered crystallinity, particle size, and thermal stability. Such alterations in the Trivedi Effect® Treated flutamide may confirm its better designing in the form of nutraceutical and pharmaceutical formulations by providing better compactibility, flowability, and content uniformity, which might be used to offer better therapeutic response against prostate cancer, androgen-dependent skin and hair conditions including acne, seborrhea, hirsutism, and scalp hair loss, hyperandrogenism, as well useful for feminizing hormone therapy aimed at transgender women.