Journal: Molecular Pharmaceutics & Organic Process Research PDF
Published: 31-Aug-15 Volume: 3 Issue: 2
DOI: 10.4172/2329-9053.1000128 ISSN: 2329-9053
Authors: Mahendra Kumar Trivedi, Rama Mohan Tallapragada, Alice Branton, Dahryn Trivedi, Gopal Nayak, Rakesh Kumar Mishra and Snehasis Jana*
Citation: Trivedi MK, Tallapragada RM, Branton A, Trivedi D, Nayak G, et al. (2015) Characterization of Physical, Spectral and Thermal Properties of Biofield Treated 1,2,4-Triazole. J Mol Pharm Org Process Res 3: 128. doi:10.4172/2329-9053.1000128
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Triazoles are an important class of compounds used as core molecule for the synthesis of many pharmaceutical drugs. The objective of the present research was to investigate the influence of biofield treatment on physical, spectral and thermal properties of 1,2,4-triazole. The study was performed in two groups, control and treatment. The control group remained as untreated, and biofield treatment was given to treatment group. The control and treated 1,2,4-triazole were characterized by X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC), Thermo Gravimetric analysis (TGA), Surface area analyzer, and Fourier transform infrared (FT-IR) spectroscopy. XRD analysis revealed a decrease in unit cell volume of treated 1,2,4-triazole (662.08 10-24 cm3) as compared to control sample (666.34 10-24 cm3). Similarly, a decrease in molecular weight of treated 1,2,4-triazole (69.78 g/mol) with respect to control (70.23 g/mol) was observed. Additionally, a substantial decrease in crystallite size (G) was observed in treated 1,2,4-triazole by 16.34% with respect to control. DSC analysis showed a slight increase in melting temperature of treated 1,2,4-triazole (124.22°C) as compared to control (123.76°C). Moreover, a significant increase in latent heat of fusion was noticed in treated 1,2,4-triazole by 21.16% as compared to control sample. TGA analysis showed a significant increase in maximum thermal decomposition temperature (Tmax) of treated 1,2,4-triazole (213.40°C) as compared to control (199.68°C). Surface area analysis using BET showed a substantial increase in surface area of the treated compound by 13.52% with respect to control. However, FT-IR analysis showed no structural changes in treated 1,2,4-triazole with respect to control. Overall, the result showed significant alteration of physical and thermal properties of the treated 1,2,4-triazole with respect to control.
XRD results showed a reduction in unit cell volume and molecular weight of treated 1,2,4-triazole as compared to control. A substantial decrease in crystallite size was evidenced in treated 1,2,4-triazole that may be due to compressive stress caused through biofield treatment with respect to control. DSC characterization showed a slight increase in melting temperature with respect to control. A significant increase in latent heat of fusion was observed in treated 1,2,4-triazole than the control sample. TGA showed a substantial increase in Tmax of treated compound as compared to control. This indicated the increase in thermal stability of 1,2,4-triazole after biofield treatment. The surface area was increased considerably in treated sample that may improve the solubility of the compound with respect to control. However, no significant change was found in FT-IR absorption peaks of treated 1,2,4-triazole in comparison with control. Based on results it was found that biofield treatment has significantly influenced the physical and thermal properties of treated 1,2,4-triazole. It is assumed that treated 1,2,4-triazole could be used for synthesis of pharmaceutical compounds.