Journal: Organic Chemistry Current Research PDF
Published: 01-Sep-15 Volume: 4 Issue: 3
DOI: 10.4172/2161-0401.1000146 ISSN: 2161-0401
Authors: Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak , Ragini Singh and Snehasis Jana *
Citation: Trivedi MK, Branton A, Trivedi D, Nayak G, Singh R, et al. (2015) Characterisation of Physical, Spectral and Thermal Properties of Biofield treated Resorcinol. Organic Chem Curr Res 4:146. doi:10.4172/2161-0401.1000146
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Resorcinol is widely used in manufacturing of several drugs and pharmaceutical products that are mainly used for topical ailments. The main objective of this study is to use an alternative strategy i.e., biofield treatment to alter the physical, spectral and thermal properties of resorcinol. The resorcinol sample was divided in two groups, which served as control and treated group. The treated group was given biofield treatment and both groups i.e., control and treated were analysed using X-ray diffraction (XRD), Fourier transform-infrared (FT-IR) spectroscopy, UV-Visible (UVVis) spectroscopy, Differential scanning calorimetry (DSC) and Thermogravimetric analysis (TGA). The results showed a significant decrease in crystallite size of treated sample i.e., 104.7 nm as compared to control (139.6 nm). The FT-IR and UV-Vis spectra of treated sample did not show any change with respect to control. Besides, thermal analysis data showed 42% decrease in latent heat of fusion. The onset temperature of volatilization and temperature at which maximum volatilization happened was also decreased by 16% and 12.86%, respectively. The significant decrease in crystallite size may help to improve the spreadability and hence bioavailability of resorcinol in topical formulations. Also increase in volatilization temperature might increase the rate of reaction of resorcinol when used as intermediate. Hence, biofield treatment may alter the physical and thermal properties of resorcinol and make it more suitable for use in pharmaceutical industry.
The XRD results showed the decrease in crystallite size (25%) in treated sample as compared to the control that may occur due to biofield treatment that probably produces the energy which leads to fracturing of grains into subgrains. The reduced crystallite size of treated resorcinol sample may be used to improve its bioavailability in topical preparations. The DSC analysis of treated sample showed 42.45% decrease in ?H value as compared to control, which probably occurred due to deformation of hydroxyl bond in treated sample. The biofield treatment might affect the structure rigidity of resorcinol and hence reduced the latent heat of fusion. TGA/DTG analysis revealed that onset temperature of volatilization and Tmax were decreased by 16% and 12.86%, respectively. This reduction in volatilization temperature of treated sample might be helpful for resorcinol to be used as a chemical intermediate in the synthesis of various pharmaceuticals. Hence, above study concluded that biofield treatment might alter the physical and thermal properties of resorcinol that could make it more useful in pharmaceutical industries by increasing the bioavailability and reaction kinetics.